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Development of Naturally Inspired Peptide and Protein Chemistry
- Source :
- Chemical and Pharmaceutical Bulletin. 70:748-764
- Publication Year :
- 2022
- Publisher :
- Pharmaceutical Society of Japan, 2022.
-
Abstract
- Diverse naturally occurring events relevant to proteins, including processing and post-translational modification, provide significant clues enabling advances in peptide/protein chemistry. Our motivation to synthesize large proteins prompted us to seek scientific bases utilized in synthetic experiments on the intein-mediated protein processing system. This account describes peptide/protein thioester-producing protocols whose design is based on acyl transfer reactions observed in the intein system, and the development of the stimulus-responsive amide cleavage and its application to the modulation of peptide function. Finally, several findings derived from nature-inspired research efforts, including peptide mimetic synthesis and S-protected cysteine chemistry, are described.
- Subjects :
- Drug Discovery
Proteins
Cysteine
General Chemistry
General Medicine
Peptides
Subjects
Details
- ISSN :
- 13475223 and 00092363
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Chemical and Pharmaceutical Bulletin
- Accession number :
- edsair.doi.dedup.....5ddaad1ffba25b1cac132be76cd9514f