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Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD
- Source :
- Clinical Journal of the American Society of Nephrology. 8:1494-1501
- Publication Year :
- 2013
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2013.
-
Abstract
- CKD is associated with poor cardiorespiratory fitness (CRF). This predefined substudy determined the effect of exercise training and lifestyle intervention on CRF and explored the effect on cardiovascular risk factors and cardiac and vascular function.Between February 2008 and March 2010, 90 patients with stage 3-4 CKD were screened with an exercise stress echocardiogram before enrollment. Patients (n=83) were randomized to standard care (control) or lifestyle intervention. The lifestyle intervention included multidisciplinary care (CKD clinic), a lifestyle program, and aerobic and resistance exercise training for 12 months. CRF (peak Vo2), left ventricular function, arterial stiffness, anthropometric, and biochemical data were collected at baseline and 12 months.Ten percent of randomized patients had subclinical myocardial ischemia at screening and completed the study without incident. There was no baseline difference among 72 patients who completed follow-up (36 in the lifestyle intervention group and 36 in the control group). The intervention increased peak Vo2 (2.8±0.7 ml/kg per minute versus -0.3±0.9 ml/kg per minute; P=0.004). There was small weight loss (-1.8±4.2 kg versus 0.7±3.7 kg; P=0.02) but no change in BP or lipids. Diastolic function improved (increased e' of 0.75±1.16 cm/s versus -0.47±1.0 cm/s; P=0.001) but systolic function was well preserved and did not change. The change in arterial elastance was attenuated (0.11±0.76 mmHg/ml versus 0.76±0.96 mmHg/ml; P=0.01). Δ peak Vo2 was associated with group allocation and improved body composition.Exercise training and lifestyle intervention in patients with CKD produces improvements in CRF, body composition, and diastolic function.
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
Physical fitness
Renal function
Blood Pressure
Critical Care and Intensive Care Medicine
Ventricular Function, Left
Cardiovascular Physiological Phenomena
Oxygen Consumption
Vascular Stiffness
Risk Factors
Weight loss
Internal medicine
Weight Loss
medicine
Humans
Renal Insufficiency, Chronic
Exercise physiology
Exercise
Life Style
Triglycerides
Aged
Transplantation
Ejection fraction
business.industry
Cholesterol, HDL
Cardiorespiratory fitness
Cholesterol, LDL
Original Articles
Middle Aged
medicine.disease
Diet
Blood pressure
Physical Fitness
Nephrology
Exercise Test
Cardiology
Arterial stiffness
Physical therapy
Female
medicine.symptom
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 15559041
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Clinical Journal of the American Society of Nephrology
- Accession number :
- edsair.doi.dedup.....5e24f987419e528b38b1ff346a198f19