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A New Standard in Graft-versus-Host Disease Prophylaxis? An Introduction to Blood and Marrow Transplant Clinical Trials Network 1703
- Source :
- Biol Blood Marrow Transplant
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Effective immunosuppressive regimens to prevent the development of graft-versus-host disease (GVHD) are essential to the success of allogeneic hematopoietic cell transplantation (HCT). After revolutionizing haploidentical transplantation, post-transplantation cyclophosphamide (PTCy) is now being evaluated for HCT performed from related and unrelated donors. In this setting, two recent randomized studies have demonstrated lower rates of GVHD and superior GVHD-free, relapse-free survival with PTCy as compared to conventional GVHD prophylaxis. The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) is currently conducting a large, randomized phase III, multicenter trial (BMT CTN 1703) comparing PTCy/tacrolimus/mycophenolate mofetil to tacrolimus/methotrexate as GVHD prophylaxis regimens in reduced-intensity allogeneic HCT. In this introductory manuscript, we review the ongoing study, highlight its importance to field, and explore the possible implications of results on clinical practice.
- Subjects :
- Oncology
medicine.medical_specialty
Transplantation Conditioning
Cyclophosphamide
Graft vs Host Disease
chemical and pharmacologic phenomena
Disease
Article
03 medical and health sciences
0302 clinical medicine
Bone Marrow
immune system diseases
Multicenter trial
Internal medicine
medicine
Humans
Multicenter Studies as Topic
Randomized Controlled Trials as Topic
Transplantation
business.industry
Hematopoietic Stem Cell Transplantation
Hematology
Mycophenolic Acid
medicine.disease
Tacrolimus
Clinical trial
surgical procedures, operative
Graft-versus-host disease
030220 oncology & carcinogenesis
Methotrexate
Unrelated Donors
business
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 10838791
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Biology of Blood and Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....5e2cd5b70ef3723d28f9e8237901eef3