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Long COVID 1 year after hospitalisation for COVID-19: a prospective bicentric cohort study
- Source :
- Swiss medical weekly. 151
- Publication Year :
- 2021
-
Abstract
- AIMS OF THE STUDY: There is increasing interest in better understanding of long COVID, a condition characterised by long-term sequelae — appearing or persisting after the typical convalescence period — of coronavirus disease 2019 (COVID-19). Herein, we describe long-term outcomes regarding residual symptoms and psychological distress in hospitalised patients 1 year after COVID-19. METHODS: This prospective cohort study included consecutive adult patients hospitalised for confirmed COVID-19 in two Swiss tertiary-care hospitals between March and June 2020. The primary endpoint was evidence of long COVID 1 year after discharge, defined as ≥1 persisting or new symptom related to COVID-19, from a predefined list of symptoms. Secondary endpoints included psychological distress and symptoms of post-traumatic stress disorder (PTSD). RESULTS: Among 90 patients included in the study, 63 (70%) had symptoms of long COVID 1 year after hospitalisation, particularly fatigue (46%), concentration difficulties (31%), shortness of breath (21%) and post-exertion malaise (20%). Three predictors, namely duration of hospitalisation (odds ratio [OR] 1.11, 95% confidence interval [CI] 1.00–1.22; p = 0.041), severity of illness (OR 1.19, 95% CI 1.04–1.37; p = 0.013), and self-perceived overall health status 30 days after hospitalisation (OR 0.97, 95% CI 0.94–1.00; p = 0.027) were associated with long COVID. Regarding secondary endpoints, 16 (18%) experienced psychological distress and 3 (3.3%) patients had symptoms of PTSD. CONCLUSION: A high proportion of COVID-19 patients report symptoms of long COVID 1 year after hospitalisation, which negatively affects their quality of life. The most important risk factors were severe initial presentation of COVID-19 with long hospital stays.
- Subjects :
- Pediatrics
medicine.medical_specialty
B-Lymphocytes
business.industry
SARS-CoV-2
Convalescence
media_common.quotation_subject
COVID-19
General Medicine
Odds ratio
Antibodies, Viral
Confidence interval
Quality of life
Severity of illness
medicine
Clinical endpoint
Quality of Life
Humans
business
Prospective cohort study
Switzerland
Cohort study
media_common
Subjects
Details
- ISSN :
- 14243997
- Volume :
- 151
- Database :
- OpenAIRE
- Journal :
- Swiss medical weekly
- Accession number :
- edsair.doi.dedup.....5e2f6593e9e8699dbfa52c9c7dd20c2c