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NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer
- Source :
- Oncogene. 38:5500-5515
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Non-muscle myosin IIA (NMIIA) protein plays an important role in cell cytokinesis and cell migration. The role and underlying regulatory mechanisms of NMIIA in pancreatic cancer (PC) remain elusive. We found that NMIIA is highly expressed in PC tissues and contributes to PC poor progression by using open microarray datasets from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and PC tissue arrays. NMIIA regulates β-catenin mediated EMT to promote the proliferation, migration, invasion, and sphere formation of PC cells in vitro and in vivo. NMIIA controls the β-catenin transcriptional activity by interacting with β-catenin. Moreover, MEK/ERK signaling is critical in MLC2 (Ser19) phosphorylation, which can mediate NMIIA activity and regulate Wnt/β-catenin signaling. These findings highlight the significance of NMIIA in tumor regression and implicate NMIIA as a promising candidate for PC treatment.
- Subjects :
- 0301 basic medicine
Cancer Research
Epithelial-Mesenchymal Transition
Biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Pancreatic cancer
Genetics
medicine
Humans
Neoplasm Invasiveness
Epithelial–mesenchymal transition
Neoplasm Metastasis
Wnt Signaling Pathway
Molecular Biology
beta Catenin
Cell Proliferation
Myosin Heavy Chains
Cell growth
Wnt signaling pathway
Cell migration
medicine.disease
Cell biology
Pancreatic Neoplasms
030104 developmental biology
030220 oncology & carcinogenesis
Phosphorylation
Cytokinesis
Subjects
Details
- ISSN :
- 14765594 and 09509232
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....5e42745344e2d0a868e447e2d460296c