Relationship of myocardial scar with cardiovascular disease risk factors in the diabetes control and complications trial (DCCT)/epidemiology of diabetes interventions and complications (EDIC) study

Methods The EDIC study is the observational follow-up (1994present) of the DCCT cohort. The DCCT (1983-93) was a controlled clinical trial of intensive versus conventional diabetes treatment in 1441 type 1 diabetic subjects. A total of 1019 DCCT/EDIC subjects underwent cardiovascular MRI at 28 centers in the USA and Canada during the 14th year of EDIC. MRI examination, centrally read, included left ventricular (LV) mass, volume and myocardial scar evaluation. A total of 757 eligible patients underwent 15 minute myocardial delayed enhancement MRI following intravenous administration of 0.15 mmol/kg dose of gadolinium contrast. Subjects with gadolinium allergy, dialysis, transplant or GFR < 60 mL/min/1.73 m2 were excluded from the gadolinium study. Images were evaluated for the presence and absence of myocardial scar as well as typical (infarct related) and atypical (non-infarct related) pattern of scar.