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Treatment-emergent neuroendocrine prostate cancer: molecularly driven clinical guidelines
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- An increasingly recognized mechanism of prostate cancer resistance is the transdifferentiation from adenocarcinoma to treatment-emergent neuroendocrine prostate cancer (t-NEPC), an extremely aggressive malignancy. The incidence of t-NEPC has been increasing in recent years, in part due to novel treatments that target the androgen receptor pathway. While clinicians historically had very few options for t-NEPC detection and treatment, recent research has uncovered key diagnostic tools and therapeutic targets that can be translated into improved patient care. In this article, we will outline the clinical features of t-NEPC and its molecular pathogenesis. Importantly, we will also discuss recently uncovered molecularly based strategies aimed at improving the diagnosis and treatment of t-NEPC. Finally, we will propose a unified algorithm that integrates clinical and molecular information for the clinical management of t-NEPC.
- Subjects :
- 0301 basic medicine
Economics and Econometrics
business.industry
Mechanism (biology)
Molecular pathogenesis
Forestry
Diagnostic tools
Bioinformatics
medicine.disease
Malignancy
Patient care
Androgen receptor
03 medical and health sciences
Prostate cancer
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Materials Chemistry
Media Technology
Medicine
Adenocarcinoma
business
Subjects
Details
- Language :
- English
- ISSN :
- 20450877
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....5e698e4db4abfc50d362fa023b52e9c9