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Recent advances and perspectives in the design and development of polymyxins
Recent advances and perspectives in the design and development of polymyxins
- Source :
- Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry, 2017.
-
Abstract
- Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considered as a last-line therapy to treat infections caused by multi-drug resistant Gram-negative bacteria. This review surveys the progress in understanding polymyxin structure, and their chemistry, mechanisms of antibacterial activity and nephrotoxicity, biomarkers, synergy and combination with other antimicrobial agents and antibiofilm properties. An update of recent efforts in the design and development of a new generation of polymyxin drugs is also discussed. A novel approach considering the modification of the scaffold of polymyxins to integrate metabolism and detoxification issues into the drug design process is a promising new line to potentially prevent accumulation in the kidneys and reduce nephrotoxicity.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.drug_class
Polymyxin
030106 microbiology
Antibiotics
Biology
Pharmacology
Biochemistry
03 medical and health sciences
Acquired resistance
Detoxification
Drug Discovery
medicine
Humans
Medicaments antibacterians
Polymyxins
Intensive care medicine
Molecular Structure
Organic Chemistry
Estructura molecular
Antimicrobial
Anti-Bacterial Agents
030104 developmental biology
Antibacterial agents
Molecular structure
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Dipòsit Digital de la UB, Universidad de Barcelona
- Accession number :
- edsair.doi.dedup.....5e6e4dc4e904efe07c0cf300ce4a05b1