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The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis

Authors :
Anirban Goutam Mukherjee
Uddesh Ramesh Wanjari
Pragya Bradu
Reshma Murali
Sandra Kannampuzha
Tamizhini Loganathan
George Priya Doss C
Arun Prakash B.P
Kaviyarasi Renu
Abhijit Dey
Balachandar Vellingiri
Abilash Valsala Gopalakrishnan
Source :
Critical Reviews in Oncology/Hematology. 176:103757
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

The human microbiome's role in colon and breast cancer is described in this review. Understanding how the human microbiome and metabolomics interact with breast and colon cancer is the chief area of this study. First, the role of the gut and distal microbiome in breast and colon cancer is investigated, and the direct relationship between microbial dysbiosis and breast and colon cancer is highlighted. This work also focuses on the many metabolomic techniques used to locate prospective biomarkers, make an accurate diagnosis, and research new therapeutic targets for cancer treatment. This review clarifies the influence of anti-tumor medications on the microbiota and the proactive measures that can be taken to treat cancer using a variety of therapies, including radiotherapy, chemotherapy, next-generation biotherapeutics, gene-based therapy, integrated omics technology, and machine learning.

Details

ISSN :
10408428
Volume :
176
Database :
OpenAIRE
Journal :
Critical Reviews in Oncology/Hematology
Accession number :
edsair.doi.dedup.....5e71cc4efc323c6d2c41a12f819c47f2
Full Text :
https://doi.org/10.1016/j.critrevonc.2022.103757