Figure S1, Figure S2, Figure S3, Figure S4, Figure S5, Figure S6 from Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance

Supplemental Figure 1. Bone marrow stromal cells enhance NB resistance to etoposide; Supplemental Figure 2. Overexpression of S1PR1 in CHLA-171 cells activates STAT3 and renders cells resistant to etoposide via JAK2/STAT3 signaling; Supplemental Figure 3. Elevated S1PR1 expression and STAT3 activation in etoposide-resistant CHLA-171 NB cells; Supplemental Figure 4. Taxol and JAK inhibitor effects on NB drug resistance; Supplemental Figure 5. Stattic and W146 inhibit STAT3 phosphorylation in NB drug resistant cells; Supplemental Figure 6. Crosstalk between NB cells and BM-MSC cells upregulates Sphk1.