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5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala
- Source :
- Neuron. 8(1)
- Publication Year :
- 1992
-
Abstract
- A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.
- Subjects :
- Serotonin
Indoles
Central nervous system
Tropisetron
Action Potentials
Neurotransmission
Biology
Amygdala
Membrane Potentials
Quinoxalines
medicine
Animals
Receptor
gamma-Aminobutyric Acid
Synaptic potential
6-Cyano-7-nitroquinoxaline-2,3-dione
General Neuroscience
Imidazoles
Ondansetron
Electric Stimulation
Rats
Electrophysiology
medicine.anatomical_structure
nervous system
2-Amino-5-phosphonovalerate
Receptors, Serotonin
Synapses
Excitatory postsynaptic potential
Serotonin Antagonists
Neuroscience
Subjects
Details
- ISSN :
- 08966273
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....5e7ae2c1c96bbfc75acc3ce13bebd4bf