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Sex differences between women and men with COPD: A new analysis of the 3CIA study
- Source :
- RESPIRATORY MEDICINE, r-FISABIO. Repositorio Institucional de Producción Científica, Fundación Universitaria San Pablo CEU (FUSPCEU), r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Respiratory medicine, 171:106105. W.B. Saunders Ltd, Zaguán. Repositorio Digital de la Universidad de Zaragoza, instname
- Publication Year :
- 2020
- Publisher :
- W. B. Saunders Co., Ltd., 2020.
-
Abstract
- Background: There is partial evidence that COPD is expressed differently in women than in men, namely on symptoms, pulmonary function, exacerbations, comorbidities or prognosis. There is a need to improve the characterization of COPD in females. Methods: We obtained and pooled data of 17 139 patients from 22 COPD cohorts and analysed the clinical differences by sex, establishing the relationship between these characteristics in women and the prognosis and severity of the disease. Comparisons were established with standard statistics and survival analysis, including crude and multivariate Cox-regression analysis. Results: Overall, 5355 (31.2%) women were compared with men with COPD. Women were younger, had lower pack-years, greater FEV1%, lower BMI and a greater number of exacerbations (all p < 0.05). On symptoms, women reported more dyspnea, equal cough but less expectoration (p < 0.001). There were no differences in the BODE index score in women (2.4) versus men (2.4) (p = 0.5), but the distribution of all BODE components was highly variable by sex within different thresholds of BODE. On prognosis, 5-year survival was higher in COPD females (86.9%) than in males (76.3%), p < 0.001, in all patients and within each of the specific comorbidities that we assessed. The crude and adjusted RR and 95% C.I. for death in males was 1.82 (1.69–1.96) and 1.73 (1.50–2.00), respectively. Conclusions: COPD in women has some characteristic traits expressed differently than compared to men, mainly with more dyspnea and COPD exacerbations and less phlegm, among others, although long-term survival appears better in female COPD patients.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
Multivariate statistics
medicine.medical_specialty
Time Factors
Survival
Copd patients
Disease
Comorbidity
Severity of Illness Index
Pulmonary function testing
Body Mass Index
03 medical and health sciences
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Internal medicine
Forced Expiratory Volume
medicine
Humans
COPD
Pooled data
030212 general & internal medicine
Prospective Studies
Survival analysis
Sex Characteristics
business.industry
Phlegm
Age Factors
Sputum
medicine.disease
Prognosis
respiratory tract diseases
Survival Rate
Dyspnea
030228 respiratory system
Disease Progression
Female
Sex
medicine.symptom
business
Subjects
Details
- ISSN :
- 09546111
- Database :
- OpenAIRE
- Journal :
- RESPIRATORY MEDICINE, r-FISABIO. Repositorio Institucional de Producción Científica, Fundación Universitaria San Pablo CEU (FUSPCEU), r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Respiratory medicine, 171:106105. W.B. Saunders Ltd, Zaguán. Repositorio Digital de la Universidad de Zaragoza, instname
- Accession number :
- edsair.doi.dedup.....5e883bdd9906b1af81cdb3bf1c0ea692