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Pinealocytes can not transport neurotropic viruses. Pinealo-to-retinal connection in prepubertal rats originates from pineal neurons: Light and electron microscopic immunohistochemical studies
- Source :
- Neuroscience letters. 744
- Publication Year :
- 2020
-
Abstract
- It is well established that the adult mammalian pineal body (PB), with the exception of rodents, contains nerve cell bodies. Based on our previous results we have proposed that there is a pinealo-to-retinal neuronal connection in adult hamsters and in prebubertal rats. By the time the animals reached puberty, labeled cells in the PB were not observed in rats. In the present experiment, we provide light and electron microscopic immunohistochemical evidence that the labeled cells in the PB of prepubertal rats are neurons. Pinealocytes cannot transport neurotropic viruses. Virus labeled cells do not show S-antigen immunoreactivity typical for pinealocytes of six-day-old rats. Electron microscopic investigation confirmed the neuronal nature of virus labeled cells. These neurons, similarly to that of hamsters, also establish pinealo-to-retinal connections in prepubertal rats.
- Subjects :
- 0301 basic medicine
Male
Pineal Gland
Virus
Pinealocyte
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Animals
Sexual Maturation
Rats, Wistar
Electron microscopic
Microscopy
Chemistry
General Neuroscience
Retinal
Biological Transport
Herpesvirus 1, Suid
Immunohistochemistry
Cell biology
Connection (mathematics)
Rats
Microscopy, Electron
030104 developmental biology
Animals, Newborn
Cell bodies
030217 neurology & neurosurgery
Retinal Neurons
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 744
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....5e8a2f2095060b5d8a99c39066348bc1