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Resveratrol prevents hepatic steatosis induced by hepatitis C virus core protein
- Source :
- Biotechnology Letters. 34:2205-2212
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Hepatitis C virus (HCV) core protein plays an important role in the development of hepatic steatosis in patients with chronic HCV infection. Treatment of C57BL/6 mice infected with HCV core recombinant adenoviruses with resveratrol significantly decreased hepatic triacylglycerols (TAG) while the serum TAG level was unaffected. RT-PCR and Western blotting showed that HCV core protein attenuated the expression of Sirt1 and PPAR-α, which would be reversed by resveratrol. This was also confirmed in primary mouse hepatic cells infected with HCV core protein expressing adenovirus. Thus, resveratrol may prevent against hepatic steatosis by blocking the inhibited expression of Sirt1 and PPAR-α induced by HCV core protein.
- Subjects :
- Hepatitis C virus
Blotting, Western
Genetic Vectors
Bioengineering
Hepacivirus
Resveratrol
medicine.disease_cause
Applied Microbiology and Biotechnology
Adenoviridae
Mice
chemistry.chemical_compound
Gastrointestinal Agents
Sirtuin 1
Stilbenes
medicine
Animals
PPAR alpha
In patient
Hepatitis C virus core
Cells, Cultured
Triglycerides
Reverse Transcriptase Polymerase Chain Reaction
Chemistry
Gene Expression Profiling
Viral Core Proteins
food and beverages
virus diseases
Core protein
General Medicine
Hepatitis C, Chronic
medicine.disease
Virology
Recombinant Proteins
digestive system diseases
Fatty Liver
Mice, Inbred C57BL
Blot
Liver
Hepatocytes
Hepatic stellate cell
Steatosis
hormones, hormone substitutes, and hormone antagonists
Biotechnology
Subjects
Details
- ISSN :
- 15736776 and 01415492
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Biotechnology Letters
- Accession number :
- edsair.doi.dedup.....5eabb65cc4aead2021b953c692dc3cf1