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The reliability of cerebellar brain inhibition
- Source :
- Clinical Neurophysiology. 132:2365-2370
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objective Connectivity between the cerebellum and primary motor cortex (M1) can be assessed by using transcranial magnetic stimulation to measure cerebellar brain inhibition (CBI). The aim of the present study was to determine the intra- and inter-day measurment error and relative reliability of CBI. The former informs the degree to which repeated measurements vary, whereas the latter informs how well the measure can distinguish individuals from one another within a sample. Methods We obtained CBI data from 83 healthy young participants (n = 55 retrospective). Intra-day measurements were separated by ~ 30 min. Inter-day measurmenets were separated by a minimum of 24 h. Results We show that CBI has low measurement error (~15%) within and between sessions. Using the measurment error, we demonstrate that change estimates which exceed measurment noise are large at an individual level, but can be detected with modest sample sizes. Finally, we demonstrate that the CBI measurement has fair to good relative reliability in healthy individuals, which may be deflated by low sample heterogeneity. Conclusions CBI has low measurement error supporting its use for tracking intra- and inter-day changes in cerebellar-M1 connectivity. Significance Our findings provide clear reliability guidelines for future studies assessing modulation of cerebellar-M1 connectivity with intervention or disease progression.
- Subjects :
- Adult
Male
medicine.medical_specialty
Future studies
Adolescent
medicine.medical_treatment
Sample (statistics)
Audiology
Cohort Studies
Young Adult
Cerebellum
Physiology (medical)
medicine
Humans
Reliability (statistics)
Retrospective Studies
Observational error
Electromyography
business.industry
Disease progression
Reproducibility of Results
Neural Inhibition
Transcranial Magnetic Stimulation
Sensory Systems
Transcranial magnetic stimulation
Neurology
Sample size determination
Female
Neurology (clinical)
Primary motor cortex
business
human activities
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....5ebd20a267de9b0d0325b7f62e5ef73f