Some anticholinergic-like behavioural effects of trans (?)-?8 tetrahydrocannabinol

Mice were intraperitoneally dosed with trans(−)-Δ8 tetrahydrocannabinol, various anticholinergic agents, hallucinogenics, or other behaviourally active drugs immediately prior to a habituating experience. The anticholinergic agents and trans(−)-Δ8 tetrahydrocannabinol inhibited the subsequent influence of the habituating experience relative to the other drugs and to solvent treated subjects. The habituation modifying effects of these drugs were antagonized by tacrine, but not by d-amphetamine. The results suggest that the behavioural effects of tetrahydrocannabinols might involve an anticholinergic mechanism.