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NTCP opens the door for hepatitis B virus infection
- Source :
- Antiviral Research. 121:24-30
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- A liver bile acids transporter, sodium taurocholate cotransporting polypeptide (NTCP, encoded by SLC10A1) was recently identified as a functional receptor for hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). NTCP-complemented human hepatoma HepG2 cells (HepG2-NTCP) were shown to support infection of HBV and HDV in vitro, providing a much-needed and convenient cell culture system for the viruses. Identification of NTCP as a functional receptor for HBV has significantly advanced our understanding of the viral life cycle and opened new opportunities for developing anti-HBV interventions. This article forms part of a symposium in Antiviral Research on “An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis B”.
- Subjects :
- Hepatitis B virus
viruses
Organic Anion Transporters, Sodium-Dependent
medicine.disease_cause
digestive system
Hepatitis B virus PRE beta
Viral life cycle
Antigen
Virology
medicine
Humans
Pharmacology
SLC10A1
Symporters
biology
virus diseases
Hep G2 Cells
Virus Internalization
Hepatitis B
biology.organism_classification
medicine.disease
digestive system diseases
Hepatocytes
biology.protein
Receptors, Virus
Satellite (biology)
Hepatitis D virus
Hepatitis Delta Virus
Subjects
Details
- ISSN :
- 01663542
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Antiviral Research
- Accession number :
- edsair.doi.dedup.....5f098c7896ef45bbd478ab4ecadce1fa