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Safety and efficacy of combined high-dose treatment with calcipotriol ointment and solution in patients with psoriasis
- Source :
- Dermatology, 204, 3, pp. 214-21, Dermatology, 204, 214-21
- Publication Year :
- 2002
-
Abstract
- Background: In the vast majority of psoriatic patients, psoriatic lesions are localised on the body as well as on the scalp. Therefore, safety data on the combined use of calcipotriol in lotion and calcipotriol in ointment are needed. Objective: This study investigated the effect of high-dose treatment with a combination of calcipotriol ointment and scalp solution on calcium metabolism, indices of bone turnover and PASI in patients with extensive psoriasis. Methods: Following a 2-week wash-out period, 88 patients were randomised to 4 weeks of treatment with either calcipotriol ointment/scalp solution (80–100 g/week and 30–50 ml/week, respectively; n = 41) or with a dithranol/tar regimen (n = 47). Patients were seen at weeks 1, 2 and 4 during treatment and 1 week following cessation of treatment. Results: No significant differences at the end of treatment were found between the 2 groups with respect to 24-hour urinary excretion of calcium (expressed as calcium/creatinine ratio), phosphate or pyridinoline, serum concentrations of calcium (albumin corrected), creatinine, phosphate, parathyroid hormone, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, osteocalcin, alkaline phosphatase (total and bone-specific iso-enzymes) or 1-collagen telopeptide. At the end of treatment, the psoriasis area and severity index had decreased by 57.4% in the calcipotriol group and by 36.1% in the dithranol/tar group (p = 0.004). Investigators’ and patients’ assessments of overall efficacy also favoured treatment with calcipotriol (p < 0.001). Conclusion: The combined use of calcipotriol ointment/scalp solution did not affect the indices of calcium metabolism or bone turnover and was significantly more effective than dithranol/tar in reducing disease severity and extent in patients with extensive psoriasis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Calcitriol
medicine.medical_treatment
Administration, Topical
Dermatology
Severity of Illness Index
law.invention
Ointments
chemistry.chemical_compound
Pharmacotherapy
Randomized controlled trial
law
Psoriasis
Medicine
Humans
Calcipotriol
Aged
Probability
Chemotherapy
Analysis of Variance
Dose-Response Relationship, Drug
business.industry
Epidermal differentiation and cutaneous inflammation
Anthralin
Middle Aged
medicine.disease
Surgery
Clinical trial
Solutions
medicine.anatomical_structure
Treatment Outcome
chemistry
Scalp
Epidermale differentiatie en cutane ontstekingsprocessen
Drug Therapy, Combination
Female
business
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 10188665
- Volume :
- 204
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Dermatology (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....5f1f02bfdadf41f99e399958ab6092af