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Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice
- Source :
- Amino Acids. 39:871-886
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Information on systematic analysis of olfactory memory-related proteins is poor. In this study, the odor discrimination task to investigate olfactory recognition memory of adult male C57BL/6J mice was used. Subsequently, olfactory bulbs (OBs) were taken, proteins extracted, and run on two-dimensional gel electrophoresis with in-gel-protein digestion, followed by mass spectrometry and quantification of differentially expressed proteins. Dual specificity mitogen-activated protein kinase kinase 1 (MEK1), dihydropyrimidinase-related protein 1 (DRP1), and fascin are related with Lemon odor memory. Microtubule-associated protein RP/EB family member 3 is related to Rose odor memory. Hypoxanthine-guanine phosphoribosyltransferase is related with both Lemon and Rose odors memory. MEK1 and DRP1 levels were increased, while microtubule-associated protein RP/EB family member 3, fascin and hypoxanthine-guanine phosphoribosyltransferase levels were decreased during olfactory memory. In summary, neurogenesis, signal transduction, cytoskeleton, and nucleotide metabolism are involved in olfactory memory formation and storage of C57BL/6J mice.
- Subjects :
- Male
biology
Molecular Sequence Data
Organic Chemistry
Clinical Biochemistry
Neurogenesis
Proteins
Olfactory Perception
Olfactory Bulb
Biochemistry
Cell biology
Olfactory bulb
Mice, Inbred C57BL
Mice
Odor
Odorants
biology.protein
Animals
Phosphoribosyltransferase
Olfactory memory
Signal transduction
Protein kinase A
Fascin
Subjects
Details
- ISSN :
- 14382199 and 09394451
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Amino Acids
- Accession number :
- edsair.doi.dedup.....5f219c2fd9673e570dc3ace82b90441c