Three-dimensional analysis of tooth dimensions in the MSX1-missense mutation

Authors :: L.M. Verhamme
Marie-José H. van den Boogaard
W.M.M. Fennis
Marco S. Cune
Carine Carels
Anne Marie Kuijpers-Jagtman
Thomas J.J. Maal
Marijn Créton
Personalized Healthcare Technology (PHT)
Source :: Clinical Oral Investigations, 17, 5, pp. 1437-45, Clinical Oral Investigations, 17(5), 1437-1445. SPRINGER HEIDELBERG, Clinical Oral Investigations, 17, 1437-45
Publication Year :: 2012
Publisher :: Springer Science and Business Media LLC, 2012.
Abstract: Item does not contain fulltext OBJECTIVES: A novel, 3D technique to measure the differences in tooth crown morphology between the MSX1 cases and non-affected controls was designed to get a better understanding of dental phenotype-genotype associations. MATERIALS AND METHODS: Eight Dutch subjects from a single family with tooth agenesis, all with an established nonsense mutation c.332 C > A, p. Ser 111 Stop in exon 1 of MSX1, were compared with unaffected controls regarding several aspects of tooth crown morphology of incisor and molar teeth. A novel method of quantitative three-dimensional analysis was used to detect differences. RESULTS: Statistically significant shape differences were observed for the maxillary incisor in the MSX1 family compared with the controls on the following parameters: surface area, buccolingual dimension, squareness, and crown volume (P