Back to Search
Start Over
Skin autofluorescence predicts major adverse cardiovascular events in patients with type 1 diabetes: a 7-year follow-up study
- Source :
- Cardiovascular Diabetology, Vol 17, Iss 1, Pp 1-7 (2018), Cardiovascular Diabetology
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Advanced glycation end-products play a role in diabetic vascular complications. Their optical properties allow to estimate their accumulation in tissues by measuring the skin autofluorescence (SAF). We searched for an association between SAF and major adverse cardiovascular events (MACE) incidence in subjects with Type 1 Diabetes (T1D) during a 7 year follow-up. Methods During year 2009, 232 subjects with T1D were included. SAF measurement, clinical [age, sex, body mass index (BMI), comorbidities] and biological data (HbA1C, blood lipids, renal parameters) were recorded. MACE (myocardial infarction, stroke, lower extremity amputation or a revascularization procedure) were registered at visits in the center or by phone call to general practitioners until 2016. Results The participants were mainly men (59.5%), 51.5 ± 16.7 years old, with BMI 25.0 ± 4.1 kg/m2, diabetes duration 21.5 ± 13.6 years, HbA1C 7.6 ± 1.1%. LDL cholesterol was 1.04 ± 0.29 g/L, estimated Glomerular Filtration Rates (CKD-EPI): 86.3 ± 26.6 ml/min/1.73 m2. Among these subjects, 25.1% were smokers, 45.3% had arterial hypertension, 15.9% had elevated AER (≥ 30 mg/24 h), and 9.9% subjects had a history of previous MACE. From 2009 to 2016, 22 patients had at least one new MACE: 6 myocardial infarctions, 1 lower limb amputation, 15 revascularization procedures. Their SAF was 2.63 ± 0.73 arbitrary units (AU) vs 2.08 ± 0.54 for other patients (p = 0.002). Using Cox-model, after adjustment for age (as the scale time), sex, diabetes duration, BMI, hypertension, smoking status, albumin excretion rates, statin treatment and a previous history of MACE, higher baseline levels of SAF were significantly associated with an increased risk of MACE during follow-up (HR = 4.13 [1.30–13.07]; p = 0.02 for 1 AU of SAF) and Kaplan–Meier curve follow-up showed significantly more frequent MACE in group with SAF upper the median (p = 0.001). Conclusion A high SAF predicts MACE in patients with T1D. Electronic supplementary material The online version of this article (10.1186/s12933-018-0718-8) contains supplementary material, which is available to authorized users.
- Subjects :
- Adult
Glycation End Products, Advanced
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Revascularization
03 medical and health sciences
Skin autofluorescence
0302 clinical medicine
Predictive Value of Tests
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Macroangiopathy
Myocardial infarction
cardiovascular diseases
Advanced glycation end-products
Stroke
Original Investigation
Aged
Skin
Angiology
2. Zero hunger
Type 1 diabetes
business.industry
Middle Aged
Prognosis
medicine.disease
3. Good health
Diabetes Mellitus, Type 1
Cardiovascular Diseases
lcsh:RC666-701
Luminescent Measurements
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
Biomarkers
Mace
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....5f2c41cfbef7737659ed9004eaebbbbc