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Association between interleukin-8 gene -251 A/T polymorphism and the risk of coronary artery disease: A meta-analysis
- Source :
- Medicine
- Publication Year :
- 2019
-
Abstract
- Background: The association between interleukin-8 (IL-8) gene polymorphism −251 A>T and susceptibility to coronary artery disease (CAD) has been investigated previously; however, results remain controversial. Thus, a meta-analysis was conducted to reassess the effects of this polymorphism on CAD risks. Methods: The PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for relevant studies published up to December, 2018. The pooled odds ratios (OR) were calculated using STATA 13.0 software for allelic (A vs T) as well as homozygote (AA vs TT), heterozygote (AT vs TT), recessive (AA vs AT + TT), and dominant (AA + AT vs TT) genotype models, respectively. Results: Ten case-control studies (3744 cases and 3660 controls) were included. Overall, a significant association of IL-8 gene −251 A > T polymorphism with an increased risk of CAD was only observed in the dominant genotype model (OR = 1.48), but not others. In the subgroup analysis, significantly increased risks were also found for Chinese (OR = 1.64), polymerase chain reaction-restriction fragment length polymorphism genotyping (OR = 1.61), acute coronary syndrome (ACS) type (OR = 1.92 for 3 datasets; OR = 1.88 for 4 datasets), high quality (OR = 1.64), and age/gender matching status (OR = 1.55) under the dominant model. Furthermore, significantly increased risks were also found for ACS type under allelic (OR = 1.32 for 3 datasets; OR = 127 for 4 datasets), homozygote (OR = 1.64 for 3 datasets; OR = 1.50 for 4 datasets), heterozygote (OR = 1.32 for 3 datasets; OR = 1.30 for 4 datasets), and recessive (OR = 1.40 for 3 datasets; OR = 1.28 for 4 datasets) models. Conclusion: This meta-analysis suggests that Chinese patients carrying −251A allele of IL-8 may have an increased risk for the development of CAD, especially ACS.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
China
Heterozygote
Genotype
Coronary Artery Disease
polymorphism
03 medical and health sciences
0302 clinical medicine
Asian People
Internal medicine
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
030212 general & internal medicine
Allele
Acute Coronary Syndrome
Genotyping
Alleles
Aged
business.industry
Homozygote
Interleukin-8
Case-control study
Heterozygote advantage
General Medicine
Odds ratio
Middle Aged
meta-analysis
030220 oncology & carcinogenesis
Meta-analysis
Case-Control Studies
Female
Gene polymorphism
business
Polymorphism, Restriction Fragment Length
Systematic Review and Meta-Analysis
Research Article
Subjects
Details
- ISSN :
- 15365964
- Volume :
- 98
- Issue :
- 48
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....5f732f3f5d5dd3478e67770caf08bf0f