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Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer
- Source :
- EBioMedicine
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Background OGN could modify tissue inflammation and immune response via local and circulating innate immune cells, which was suggestive of a reciprocal relationship between OGN and T cell infiltration in cancer. Hence, we aim to measure the OGN expression patterns and immune cells response in colorectal cancer(CRC). Methods This study enrolled three independent sets of patients from TCGA and the Fudan University Shanghai Cancer Center(FUSCC). The effect of OGN on T cell infiltration and the mechanism were examined in vitro and in vivo. Findings Tumor OGN expression levels were positively associated with CD3, CD8, and PTPRC expressions in the training and testing sets from TCGA, respectively. In validation set from FUSCC, OGN expression level also paralleled positively with CD8+ cell density in colorectal cancer tissue (p<br />Highlights • OGN is positively associated with T cell density in CRC • OGN inhibited the activation of HIF-1α, then significantly impeded the expression of VEGF.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
0301 basic medicine
Survival
Colorectal cancer
CD3
T-Lymphocytes
PTPRC
General Biochemistry, Genetics and Molecular Biology
Tumor-infiltrating lymphocytes
03 medical and health sciences
Lymphocytes, Tumor-Infiltrating
0302 clinical medicine
Immune system
Cell Line, Tumor
medicine
Animals
Humans
Immune response
Aged
Innate immune system
biology
Neovascularization, Pathologic
business.industry
Osteoglycin
Cancer
General Medicine
Middle Aged
Hypoxia-Inducible Factor 1, alpha Subunit
medicine.disease
ErbB Receptors
Mice, Inbred C57BL
030104 developmental biology
030220 oncology & carcinogenesis
Commentary
Cancer research
biology.protein
Intercellular Signaling Peptides and Proteins
Female
Colorectal Neoplasms
business
CD8
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 23523964
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- EBioMedicine
- Accession number :
- edsair.doi.dedup.....5f8fa623d4aef10ade97f8587f802efd