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Early and delayed evaluation of solid tumours with 64Cu-ATSM PET/CT
- Source :
- Nuclear Medicine Communications. 38:340-346
- Publication Year :
- 2017
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2017.
-
Abstract
- OBJECTIVE: The aim of this study was to analyse early and delayed acquisition on copper-64 diacetyl-bisN4-methylthiosemicarbazone (Cu-ATSM) PET/CT in a small cohort of patients by comparing semiquantitative and computer-aided fractal geometry analyses. PATIENTS AND METHODS: Five cancer patients, including non-small-cell lung cancer and head and neck cancer, were investigated with Cu-ATSM PET/CT. Participants received an intravenous injection of Cu-ATSM according to body size and were imaged 60 min (early) and 16 h (delayed) later on hybrid PET/CT. Reconstructed images were visualized on advanced workstations for the definition of semiquantitative parameters: standardized uptake value (SUV)max, SUVratio-to-muscle, SUVmean, hypoxic volume (HV) and hypoxic burden (HB=HV×SUVmean). DICOM data retrieved from both scans were analysed using an ad-hoc computer program to determine the mean intensity value, SD, relative dispersion, three-dimensional histogram fractal dimension and three-dimensional fractal dimension. RESULTS: All tumour lesions showed increased uptake of Cu-ATSM at early evaluation, with a median SUVratio-to-muscle of 4.42 (range: 1.58-5.62), a median SUVmax of 5.3 (range: 1.9-7.3), a median SUVmean of 2.8 (range: 1.5-3.9), a median HV of 41.6 cm (range: 2.8-453.7) and a median HB of 161.5 cm (range: 4.4-1112.5). All semiquantitative data obtained at 1 h were consistent with the parameters obtained on delayed imaging (P>0.05). A borderline statistically significant difference was found only for SUVmax of the muscle (P=0.045). Fractal geometry analysis on DICOM images showed that all parameters at early imaging showed no statistically significant difference with late acquisition (P>0.05). CONCLUSION: Our findings support the consistency of Cu-ATSM PET/CT images obtained at early and delayed acquisition for the assessment of tumour lesions.
- Subjects :
- Male
Thiosemicarbazones
Lung Neoplasms
positron emission tomography
Pilot Projects
030218 nuclear medicine & medical imaging
03 medical and health sciences
hypoxia imaging
0302 clinical medicine
Fractal
fractal
Coordination Complexes
delayed imaging
Carcinoma, Non-Small-Cell Lung
Positron Emission Tomography Computed Tomography
Image Interpretation, Computer-Assisted
Organometallic Compounds
medicine
Humans
Delayed imaging
Radiology, Nuclear Medicine and imaging
copper-64 diacetyl-bisN4-methylthiosemicarbazone
Aged
Positron Emission Tomography-Computed Tomography
PET-CT
business.industry
Cancer
computed tomography
General Medicine
Middle Aged
medicine.disease
Fractals
Copper Radioisotopes
Head and Neck Neoplasms
early imaging
030220 oncology & carcinogenesis
Computer-aided
Female
Radiopharmaceuticals
Nuclear medicine
business
image analysi
Subjects
Details
- ISSN :
- 01433636
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine Communications
- Accession number :
- edsair.doi.dedup.....5f9318e6888e77c7803b41a67542a86d