Back to Search
Start Over
Thyroid dysfunction in patients with childhood-onset medulloblastoma or primitive neuroectodermal tumor
- Source :
- Annals of Pediatric Endocrinology & Metabolism, Vol 23, Iss 2, Pp 88-93 (2018), Annals of Pediatric Endocrinology & Metabolism
- Publication Year :
- 2018
- Publisher :
- Korean Society of Pediatric Endocrinology, 2018.
-
Abstract
- Purpose We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). Methods The medical records of 66 patients (42 males) treated for medulloblastoma (n=56) or PNET (n=10) in childhood between January 2000 and December 2014 at Seoul National University Children's Hospital were retrospectively reviewed. A total of 21 patients (18 high-risk medulloblastoma and 3 PNET) underwent high-dose chemotherapy and autologous stem cell rescue (HDCT/ASCR). Results During the median 7.6 years of follow-up, 49 patients (74%) developed transient (n=12) or permanent (n=37) hypothyroidism at a median 3.8 years of follow-up (2.9-4.6 years). Younger age (l5 years) at radiation exposure (P=0.014 vs. ≥9 years) and HDCT (P=0.042) were significantly predictive for hypothyroidism based on log-rank test. However, sex, type of tumor, and dose of craniospinal irradiation (less vs. more than 23.4 Gy) were not significant predictors. Cox proportional hazard model showed that both younger age (l5 years) at radiation exposure (hazard ratio [HR], 3.1; vs. ≥9 years; P=0.004) and HDCT (HR, 2.4; P=0.010) were significant predictors of hypothyroidism. Conclusion Three-quarters of patients with pediatric medulloblastoma or PNET showed thyroid dysfunction, and over half had permanent thyroid dysfunction. Thus, frequent monitoring of thyroid function is mandatory in all patients treated for medulloblastoma or PNET, especially, in very young patients and/or high-risk patients recommended for HDCT/ASCR.
- Subjects :
- Pediatrics
medicine.medical_specialty
Thyroid hormones
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
03 medical and health sciences
0302 clinical medicine
medicine
Chemotherapy
030212 general & internal medicine
Adjuvant
Primitive neuroectodermal tumors
Medulloblastoma
Proportional hazards model
business.industry
Medical record
Hazard ratio
lcsh:RJ1-570
Craniospinal irradiation
lcsh:Pediatrics
medicine.disease
Radiation therapy
030220 oncology & carcinogenesis
Primitive neuroectodermal tumor
Pediatrics, Perinatology and Child Health
Original Article
Thyroid function
business
Subjects
Details
- Language :
- English
- ISSN :
- 22871292 and 22871012
- Volume :
- 23
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of Pediatric Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....5f9850a51664c54e32cd3d6af1948e28