Back to Search
Start Over
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders
- Source :
- Cellular and Molecular Life Sciences, Spaas, J, van Veggel, L, Schepers, M, Tiane, A, van Horssen, J, Wilson, D M, Moya, P R, Piccart, E, Hellings, N, Eijnde, B O, Derave, W, Schreiber, R & Vanmierlo, T 2021, ' Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders ', Cellular and Molecular Life Sciences, vol. 78, no. 10, pp. 4615-4637 . https://doi.org/10.1007/s00018-021-03802-0, CELLULAR AND MOLECULAR LIFE SCIENCES
- Publication Year :
- 2021
-
Abstract
- Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that occurs due to brain injury or inflammation-induced demyelination (remyelination) but are also pivotal in plastic processes such as learning and memory (adaptive myelination). OPC differentiation into mature myelinating oligodendrocytes is controlled by a complex transcriptional network and depends on high metabolic and mitochondrial demand. Mounting evidence shows that OPC dysfunction, culminating in the lack of OPC differentiation, mediates the progression of neurodegenerative disorders such as multiple sclerosis, Alzheimer’s disease and Parkinson’s disease. Importantly, neurodegeneration is characterised by oxidative and carbonyl stress, which may primarily affect OPC plasticity due to the high metabolic demand and a limited antioxidant capacity associated with this cell type. The underlying mechanisms of how oxidative/carbonyl stress disrupt OPC differentiation remain enigmatic and a focus of current research efforts. This review proposes a role for oxidative/carbonyl stress in interfering with the transcriptional and metabolic changes required for OPC differentiation. In particular, oligodendrocyte (epi)genetics, cellular defence and repair responses, mitochondrial signalling and respiration, and lipid metabolism represent key mechanisms how oxidative/carbonyl stress may hamper OPC differentiation in neurodegenerative disorders. Understanding how oxidative/carbonyl stress impacts OPC function may pave the way for future OPC-targeted treatment strategies in neurodegenerative disorders.
- Subjects :
- 0301 basic medicine
Cell type
Central nervous system
Oxidative phosphorylation
Review
Biology
medicine.disease_cause
03 medical and health sciences
Cellular and Molecular Neuroscience
Myelination
0302 clinical medicine
Oligodendrocyte precursor cell
medicine
Medicine and Health Sciences
Animals
Humans
Remyelination
Neurodegeneration
Molecular Biology
Pharmacology
Oligodendrocyte Precursor Cells
Multiple sclerosis
Carbonyl stress
Biology and Life Sciences
Cell Differentiation
Cell Biology
medicine.disease
Oligodendrocyte
Cell biology
Oxidative Stress
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
nervous system
Oxidative stress
Molecular Medicine
Nervous System Diseases
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 1420682X and 14209071
- Volume :
- 78
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....5f9b1af3fb7aed57f30ae9595bd0749e