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Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score
- Source :
- Clinical Endocrinology. 89:148-154
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- OBJECTIVE Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Our aim was to compare vertebral BMD and TBS in patients with overt CS and mild autonomous cortisol secretion (MACE), and following cure of overt CS. SETTING University Hospital. DESIGN Monocentric retrospective cross-sectional and longitudinal studies of consecutive patients. PATIENTS A total of 110 patients were studied: 53 patients had CS (35, 11 and 7 patients with Cushing's disease, bilateral macronodular adrenal hyperplasia and ectopic ACTH secretion respectively); 39 patients had MACE (10 patients with a late post-operative recurrence of Cushing's disease and 29 patients with adrenal incidentalomas); 18 patients with non-secreting adrenal incidentalomas. 14 patients with overt CS were followed for up to 2 years after cure. RESULTS Vertebral osteoporosis at BMD and degraded microarchitecture at TBS were found in 24% and 43% of patients with CS, respectively (P
- Subjects :
- 0301 basic medicine
Cortisol secretion
medicine.medical_specialty
S syndrome
business.industry
Endocrinology, Diabetes and Metabolism
Osteoporosis
Urology
030209 endocrinology & metabolism
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Endocrinology
Normal bone
Trabecular bone score
Internal medicine
Macronodular Adrenal Hyperplasia
medicine
Etiology
business
Mace
Subjects
Details
- ISSN :
- 03000664
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Clinical Endocrinology
- Accession number :
- edsair.doi.dedup.....5fce3aab440eeaad703a814bec666831