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A decade of genome sequencing has revolutionized studies of experimental evolution
- Source :
- Current opinion in microbiology. 45
- Publication Year :
- 2018
-
Abstract
- Genome sequencing has revolutionized studies using experimental evolution of microbes because it readily provides comprehensive insight into the genetic bases of adaptation. In this perspective we discuss applications of sequencing-based technologies used to study evolution in microbes, including genomic sequencing of isolated evolved clones and mixed evolved populations, and also the use of sequencing methods to follow the fate of introduced variations, whether neutral barcodes or variants introduced by genome editing. Collectively, these sequencing-based approaches have vastly advanced the examination of evolution in the lab, as well as begun to synthesize this work with examination of the genetic bases of adaptation and evolutionary dynamics within natural populations.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Experimental evolution
Bacteria
Whole Genome Sequencing
Genomic sequencing
High-Throughput Nucleotide Sequencing
Computational biology
Biology
Microbiology
DNA sequencing
Evolution, Molecular
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Infectious Diseases
Genome editing
Adaptation
Evolutionary dynamics
030217 neurology & neurosurgery
Genome, Bacterial
Subjects
Details
- ISSN :
- 18790364
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Current opinion in microbiology
- Accession number :
- edsair.doi.dedup.....5ff9103a9f007be387abb1f448e81cb1