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Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides
- Source :
- Chemical Communications. 53:5565-5568
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.
- Subjects :
- Apoptosis
02 engineering and technology
010402 general chemistry
01 natural sciences
Catalysis
Self assembled
Mice
chemistry.chemical_compound
Cell Line, Tumor
Materials Chemistry
Animals
Humans
Secretion
Tumor Necrosis Factor-alpha
Chemistry
Metals and Alloys
hemic and immune systems
DNA
General Chemistry
Cpg oligonucleotides
021001 nanoscience & nanotechnology
Molecular biology
Coculture Techniques
Nanostructures
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Cell biology
RAW 264.7 Cells
Oligodeoxyribonucleotides
Cancer cell
Ceramics and Composites
Cytokines
0210 nano-technology
Cpg odns
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....600039ad075a60b93b7a4dc6d7766858