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Phenolic compounds from the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. And their lipid-lowering effects
- Source :
- Bioorganicmedicinal chemistry letters. 47
- Publication Year :
- 2021
-
Abstract
- A phytochemical study on the leaves of Crataegus pinnatifida Bge. var. major N.E.Br. was carried out, which finally led to the isolation of nineteen phenolic compounds (1-19). The structures of all compounds were established mainly by NMR and MS spectroscopic analysis as well as the necessary ECD experimental evidence, of which compounds 1-4 (crataegunins A-D) were identified as new phenylpropanoid-substituted epicatechins. HepG2 cells were induced by oleic acid and palmitic acid to establish the model of lipid metabolism disorder. All isolated compounds were used to intervene in the model, and the contents of triglyceride (TG) and total cholesterol (TC) were detected. Compound 2 could significantly reduce the content of TG, while compounds 2 and 11 both have good activity in reducing TC content.
- Subjects :
- Lipid Metabolism Disorder
Cell Survival
Rosaceae
Clinical Biochemistry
Pharmaceutical Science
01 natural sciences
Biochemistry
Palmitic acid
chemistry.chemical_compound
Structure-Activity Relationship
Phenols
Drug Discovery
Humans
Molecular Biology
Triglycerides
Crataegus
Chromatography
biology
Triglyceride
Dose-Response Relationship, Drug
Molecular Structure
010405 organic chemistry
Organic Chemistry
Hep G2 Cells
biology.organism_classification
Crataegus pinnatifida
0104 chemical sciences
Plant Leaves
010404 medicinal & biomolecular chemistry
Oleic acid
chemistry
Phytochemical
Molecular Medicine
Lipid lowering
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....6018d2d36bf99a79139bd08aa4fe2fc5