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Human organoids: a new dimension in cell biology
- Source :
- Molecular Biology of the Cell
- Publication Year :
- 2019
- Publisher :
- American Society for Cell Biology (ASCB), 2019.
-
Abstract
- Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public.
- Subjects :
- Biomedical Research
ved/biology.organism_classification_rank.species
Cell Culture Techniques
Computational biology
Biology
Regenerative Medicine
Models, Biological
Regenerative medicine
03 medical and health sciences
0302 clinical medicine
Tissue engineering
Organoid
Animals
Humans
Model organism
Molecular Biology
030304 developmental biology
0303 health sciences
Tissue Engineering
Task force
ved/biology
Stem Cells
Reproducibility of Results
Cell Biology
Medical research
Organoids
Drug development
Perspective
Stem cell
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19394586 and 10591524
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Molecular Biology of the Cell
- Accession number :
- edsair.doi.dedup.....60213ffe7a3c55abcb8f7f593f28bcc0
- Full Text :
- https://doi.org/10.1091/mbc.e19-03-0135