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Human organoids: a new dimension in cell biology

Authors :
Ruth Lehmann
Kevin M. Wilson
Brigid L.M. Hogan
Jürgen A. Knoblich
Zev J. Gartner
Connie M. Lee
Erika C. Shugart
Marta Benedetti
R. Alta Charo
Celeste M. Nelson
Source :
Molecular Biology of the Cell
Publication Year :
2019
Publisher :
American Society for Cell Biology (ASCB), 2019.

Abstract

Organoids derived from stem cells or tissues in culture can develop into structures that resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures provide the potential to study human development and model disease processes with the same scrutiny and depth of analysis customary for research with nonhuman model organisms. Resembling the complexity of the actual tissue or organ, patient-derived human organoid studies may accelerate medical research, creating new opportunities for tissue engineering and regenerative medicine, generating knowledge and tools for preclinical studies, including drug development and testing. Biologists are drawn to this system as a new “model organism” to study complex disease phenotypes and genetic variability among individuals using patient-derived tissues. The American Society for Cell Biology convened a task force to report on the potential, challenges, and limitations for human organoid research. The task force suggests ways to ease the entry for new researchers into the field and how to facilitate broader use of this new model organism within the research community. This includes guidelines for reproducibility, culturing, sharing of patient materials, patient consent, training, and communication with the public.

Details

ISSN :
19394586 and 10591524
Volume :
30
Database :
OpenAIRE
Journal :
Molecular Biology of the Cell
Accession number :
edsair.doi.dedup.....60213ffe7a3c55abcb8f7f593f28bcc0
Full Text :
https://doi.org/10.1091/mbc.e19-03-0135