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The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection
- Source :
- Scientific Reports
- Publication Year :
- 2016
-
Abstract
- The aim of this study was to explore the associations and differences in influencing factors between alcoholic liver disease (ALD) coupled with Helicobacter pylori infection and atherosclerosis and to determine whether there is a “double hit phenomenon” in atherosclerosis patients with ALD and H. pylori infections. Included cases (n = 160) were categorized into 4 groups: 41 cases of ALD coupled with H. pylori infections (group A), 35 cases of H. pylori infections without ALD (group B), 37 cases of ALD without H. pylori infections (group C), and 47 normal control cases (group D). CIMT was significantly greater in group A than in groups B and D (P = 0.005 and P = 0.001, respectively). The GLM univariate analysis found that CIMT was significantly greater in group A than in groups B, C and D (P = 0.018, P = 0.001 and P = 0.009, respectively). We found that BMI and ALT, AST and ApoB levels were independent predictors of CIMT (P = 0.000, P = 0.000, P = 0.012 and P = 0.014, respectively). ALD coupled with H. pylori infection may result in significant CIMT thickening, but H. pylori infection without ALD and ALD without H. pylori infection does not, suggesting that a “double hit phenomenon” occurs. Additionally, BMI, and ALT, AST and ApoB levels were independent risk factors for increased CIMT.
- Subjects :
- Adult
Carotid Artery Diseases
Male
Helicobacter pylori infection
medicine.medical_specialty
Alcoholic liver disease
Apolipoprotein B
030204 cardiovascular system & hematology
Group A
Gastroenterology
Carotid Intima-Media Thickness
Group B
Article
Helicobacter Infections
Correlation
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Liver Diseases, Alcoholic
Univariate analysis
Multidisciplinary
biology
Helicobacter pylori
business.industry
nutritional and metabolic diseases
Middle Aged
biology.organism_classification
medicine.disease
Atherosclerosis
biology.protein
030211 gastroenterology & hepatology
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....60219f9ba9603f947c839d770e830c0a