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Rhythm of Fetoplacental 11β-Hydroxysteroid Dehydrogenase Type 2 — Fetal Protection From Morning Maternal Glucocorticoids
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 106:1630-1636
- Publication Year :
- 2021
- Publisher :
- The Endocrine Society, 2021.
-
Abstract
- Context Excess glucocorticoids impact fetal health. Maternal glucocorticoids peak in early morning. Fetoplacental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) inactivates cortisol to cortisone, protecting the fetus from high glucocorticoids. However, time-specific alterations of human fetoplacental 11β-HSD2 have not been studied. Objective We hypothesized that fetoplacental 11β-HSD2 activity shows time-specific alteration and acute affective or anxiety disorders impact fetoplacental 11β-HSD2 activity. Methods In this observational study we investigated 78 pregnant European women undergoing amniocentesis (15.9 ± 0.9 weeks of gestation). Amniotic fluid was collected (8:00 to 16:30 hours) for analysis of fetoplacental 11β-HSD2 activity, using cortisol (F):cortisone (E) ratio in amniotic fluid, E/(E + F). Fetoplacental 11β-HSD2 rhythm and association with “acute affective or anxiety disorder” (patients with at least one of: a major depressive episode, specific phobia, panic disorder, generalized anxiety disorder, mixed anxiety and depressive disorder) and “acute anxiety disorder” (one of: panic disorder, generalized anxiety disorder, mixed anxiety, depressive disorder), assessed using Mini International Neuropsychiatric Interview, were investigated. Results Activity of 11β-HSD2 correlated with time of amniocentesis, peaking in the morning (r = −0.398; P Conclusion Our study indicates a time-specific alteration of fetoplacental 11β-HSD2 activity with peaking levels in the morning, demonstrating a mechanism of fetal protection from the morning maternal glucocorticoid surge.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Generalized anxiety disorder
Placenta
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Context (language use)
Biochemistry
Specific phobia
Young Adult
Endocrinology
Pregnancy
11-beta-Hydroxysteroid Dehydrogenase Type 2
Germany
Internal medicine
medicine
Humans
Placental Circulation
Major depressive episode
Glucocorticoids
Morning
business.industry
Panic disorder
Biochemistry (medical)
Middle Aged
Amniotic Fluid
medicine.disease
Anxiety Disorders
Circadian Rhythm
Pregnancy Complications
Maternal-Fetal Relations
Amniocentesis
Anxiety
Female
medicine.symptom
business
Stress, Psychological
Anxiety disorder
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....602c3e123e04ecf1048554064c41c39d