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HIV-1 LTR Subtype and Perinatal Transmission

Authors :
Donna Spiegelman
Boris Renjifo
Ellen Hertzmark
Wafaie W. Fawzi
David J. Hunter
Gernard I. Msamanga
Jason T. Blackard
Davis Mwakagile
Neda Sharghi
Charles Kagoma
Max Essex
Source :
Virology. 287(2):261-265
Publication Year :
2001
Publisher :
Elsevier BV, 2001.

Abstract

Multiple subtypes of HIV-1 have been identified; however, there is little data on the relative transmissibility of viruses belonging to different subtypes. A matched case-control study addressed whether viruses with different long terminal repeat (LTR) subtypes were transmitted equally from mother to infant. The LTR subtype was determined for 45 matched cases and controls who participated in a clinical trial in Tanzania. HIV-1 subtypes A, C, and D and intersubtype recombinant sequences were identified. Exact matched logistic regression analysis showed that viruses containing subtype A or intersubtype recombinant LTRs were 3.2 and 4.8 times more likely to be transmitted from mother to infant than viruses with subtype D LTRs. Viruses containing subtype C LTRs were 6.1 times more likely to be transmitted than those with subtype D LTRs. These differences in transmission were independent of maternal CD4 at enrollment. Thus, it appears that HIV-1 subtype may be associated with differing rates of perinatal transmission in Tanzania.

Details

ISSN :
00426822
Volume :
287
Issue :
2
Database :
OpenAIRE
Journal :
Virology
Accession number :
edsair.doi.dedup.....602cc0384bec4253f060cb0ac2dd0bd1
Full Text :
https://doi.org/10.1006/viro.2001.1059