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HIV-1 LTR Subtype and Perinatal Transmission
- Source :
- Virology. 287(2):261-265
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Multiple subtypes of HIV-1 have been identified; however, there is little data on the relative transmissibility of viruses belonging to different subtypes. A matched case-control study addressed whether viruses with different long terminal repeat (LTR) subtypes were transmitted equally from mother to infant. The LTR subtype was determined for 45 matched cases and controls who participated in a clinical trial in Tanzania. HIV-1 subtypes A, C, and D and intersubtype recombinant sequences were identified. Exact matched logistic regression analysis showed that viruses containing subtype A or intersubtype recombinant LTRs were 3.2 and 4.8 times more likely to be transmitted from mother to infant than viruses with subtype D LTRs. Viruses containing subtype C LTRs were 6.1 times more likely to be transmitted than those with subtype D LTRs. These differences in transmission were independent of maternal CD4 at enrollment. Thus, it appears that HIV-1 subtype may be associated with differing rates of perinatal transmission in Tanzania.
- Subjects :
- Perinatal transmission
viruses
Human immunodeficiency virus (HIV)
HIV Infections
Biology
medicine.disease_cause
law.invention
03 medical and health sciences
0302 clinical medicine
Fetus
law
Pregnancy
Virology
medicine
Humans
030212 general & internal medicine
030304 developmental biology
HIV Long Terminal Repeat
Genetics
Recombination, Genetic
0303 health sciences
Long terminal repeat
3. Good health
Recombinant DNA
HIV-1
Female
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 287
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....602cc0384bec4253f060cb0ac2dd0bd1
- Full Text :
- https://doi.org/10.1006/viro.2001.1059