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Multidimensional NMR methods for protein structure determination
Multidimensional NMR methods for protein structure determination
- Source :
- IUBMB life. 52(6)
- Publication Year :
- 2002
-
Abstract
- Structural studies of proteins are critical for understanding biological processes at the molecular level. Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for obtaining structural and dynamic information on proteins and protein-ligand complexes. In the present review, methodologies for NMR structure determination of proteins and macromolecular complexes are described. In addition, a number of recent advances that reduce the molecular weight limitations previously imposed on NMR studies of biomolecules are discussed, highlighting applications of these technologies to protein systems studied in our laboratories.
- Subjects :
- chemistry.chemical_classification
Models, Molecular
Magnetic Resonance Spectroscopy
Protein Conformation
Biomolecule
Spectrum Analysis
Clinical Biochemistry
Proteins
Cell Biology
Fluorine-19 NMR
Nuclear magnetic resonance spectroscopy
Biochemistry
Nuclear magnetic resonance
Molecular level
Protein structure
chemistry
Models, Chemical
Genetics
Triple-resonance nuclear magnetic resonance spectroscopy
Physical chemistry
Transverse relaxation-optimized spectroscopy
Spectroscopy
Molecular Biology
Subjects
Details
- ISSN :
- 15216543
- Volume :
- 52
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- IUBMB life
- Accession number :
- edsair.doi.dedup.....603a42af78be4c55de0bf00d760364f6