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Oxidative stress in marathon runners: interest of antioxidant supplementation
- Source :
- British Journal of Nutrition. 96:S31-S33
- Publication Year :
- 2006
- Publisher :
- Cambridge University Press (CUP), 2006.
-
Abstract
- We have recently reported that xanthine oxidase is involved in the generation of free radicals in exhaustive exercise. Allopurinol, an inhibitor of xanthine oxidase, prevents it. The aim of the present work was to elucidate the role of exercise-derived reactive oxygen species in the cell signalling pathways involved in the adaptation to exercise in man. We have found that exercise causes an increase in the activity of plasma xanthine oxidase and an activation of NF-κB in peripheral blood lymphocytes after marathon running. This activation is dependent on free radical formation in exercise: treatment with allopurinol completely prevents it. In animal models, we previously showed that NF-κB activation induced by exhaustive physical exercise leads to an increase in the expression of superoxide dismutase, an enzyme involved in antioxidant defence. We report evidence in man that reactive oxygen species act as signals in exercise as decreasing their formation prevents activation of important signalling pathways which can cause useful adaptations in cells.
- Subjects :
- Adult
Male
Xanthine Oxidase
medicine.medical_specialty
Antioxidant
Allopurinol
medicine.medical_treatment
Physical Exertion
Medicine (miscellaneous)
Physical exercise
Lymphocyte Activation
medicine.disease_cause
Antioxidants
Running
Lipid peroxidation
Superoxide dismutase
chemistry.chemical_compound
Malondialdehyde
Internal medicine
medicine
Humans
Lymphocytes
Muscle, Skeletal
Xanthine oxidase
chemistry.chemical_classification
Reactive oxygen species
Nutrition and Dietetics
biology
Chemistry
NF-kappa B
Middle Aged
Adaptation, Physiological
Oxidative Stress
Endocrinology
Muscle Fatigue
biology.protein
Lipid Peroxidation
Reactive Oxygen Species
Oxidative stress
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....60621c034d989da65d0c89f6158bee63