Combined Modeling Approach to Study the Interaction of a Cold Plasma Jet with Solid Tumors

During the past decade, computer modeling of atmospheric pressure plasma jets (APPJs) has attracted scientific attention. Particularly, several plasma fluid models (PFM) have been developed, involving commercially-available software or in-house codes, which have provided significant insight of plasma propagation mechanisms, production pathways of reactive oxygen and nitrogen species (RONS), electric field dynamics, and plasma interaction with solid/liquid targets. Combining computer models with targeted experiments, invaluable information can be obtained for the optimization of APPJs and their implementation in plasma medicine and cancer therapy. Therefore, modeling the effect of APPJs on solid tumors may offer promise in designing novel synergistic therapies (e.g., plasma with nanomedicine). The present study proposes a novel multiphysics/multiscale modeling approach that combines a PFM using COMSOL Multiphysics® and a cutting-edge in-silico framework for cancer modelling, FEB3.
Oral presentation at the 8th international conference on plasma medicine, August 2021, Icheon South Korea held online