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Alteration in abundance and compartmentalization of inflammation-related miRNAs in plasma after intracerebral hemorrhage
- Source :
- Stroke. 44(6)
- Publication Year :
- 2013
-
Abstract
- Background and Purpose— We tested the hypothesis that circulating microRNAs (miRNAs) present in plasma might display a specific signature in patients with intracerebral hemorrhage. Methods— Global miRNA profiles were determined with the Agilent Human miRNA Microarray platform, and validated by quantitative polymerase chain reaction. Results— A subset of 30 miRNAs were selectively upregulated in both male and female patients with intracerebral hemorrhage. Network analysis revealed that the most significantly overrepresented biological process associated with these miRNAs was inflammation. Unlike the plasma miRNAs in healthy controls, which were detected exclusively in the microvesicle fraction, the deregulated plasma miRNAs after intracerebral hemorrhage were present in both the microvesicle and the supernatant fractions. Conclusions— Intracerebral hemorrhage altered both the abundance and the compartmentalization of several inflammation-related miRNAs in plasma.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Inflammation
Downregulation and upregulation
microRNA
medicine
Humans
Cerebral Hemorrhage
Advanced and Specialized Nursing
Intracerebral hemorrhage
business.industry
Microvesicle
Gene Expression Profiling
Compartmentalization (psychology)
medicine.disease
Microarray Analysis
Up-Regulation
Circulating MicroRNA
MicroRNAs
Real-time polymerase chain reaction
Case-Control Studies
Encephalitis
Female
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15244628
- Volume :
- 44
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....607c7bf15e9a5bc39eb3b7bc25e535b2