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Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

Authors :
Tauani Caroline Santos França
Ana Julia Ribeiro
Luísa Natália Bolda Mariano
Ana Caroline dos Santos
Larissa Venzon
Lincon Bordignon Somensi
Ruan Kaio Silva Nunes
Camila André Cazarin
Karen Luz Okubo
Helenita Priscila Poerner
Jairo Kneupp Bastos
Márcia Maria de Souza
Luísa Mota da Silva
Source :
Evidence-Based Complementary and Alternative Medicine. 2022:1-14
Publication Year :
2022
Publisher :
Hindawi Limited, 2022.

Abstract

The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11th and 12th days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects.

Details

ISSN :
17414288 and 1741427X
Volume :
2022
Database :
OpenAIRE
Journal :
Evidence-Based Complementary and Alternative Medicine
Accession number :
edsair.doi.dedup.....60958f9c89d942eb11237eee0fee0a2f
Full Text :
https://doi.org/10.1155/2022/5833840