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Free Radicals in Exhaustive Physical Exercise: Mechanism of Production, and Protection by Antioxidants
- Source :
- ResearcherID
- Publication Year :
- 2000
- Publisher :
- Informa UK Limited, 2000.
-
Abstract
- Moderate exercise is a healthy practice. However, exhaustive exercise generates free radicals. This can be evidenced by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage. It is well known that activity of cytosolic enzymes in blood plasma is increased after exhaustive exercise. This may be taken as a sign of damage to muscle cells. The degree of oxidative stress and of muscle damage does not depend on the absolute intensity of exercise but on the degree of exhaustion of the person who performs exercise. Training partially prevents free radical-formation in exhaustive exercise. Treatment with antioxidants such as vitamins C or E protects in part against free radical-mediated damage in exercise. Xanthine oxidase is involved in free-radical formation in exercise in humans and inhibition of this enzyme with allopurinol decreases oxidative stress and muscle damage associated with exhaustive exercise. Knowledge of the mechanism of free-radical formation in exercise is important because it will be useful to prevent oxidative stress and damage associated with exhaustive physical activity.
- Subjects :
- medicine.medical_specialty
Free Radicals
Allopurinol
Physical Exertion
Clinical Biochemistry
Physical exercise
medicine.disease_cause
Biochemistry
Antioxidants
Lipid peroxidation
chemistry.chemical_compound
Internal medicine
Malondialdehyde
medicine
Genetics
Animals
Humans
Lung Diseases, Obstructive
Exercise physiology
Xanthine oxidase
Creatine Kinase
Exercise
Molecular Biology
Muscle fatigue
Glutathione Disulfide
Chemistry
Glutathione
Cell Biology
Ascorbic acid
Endocrinology
Muscle Fatigue
Oxidative stress
Subjects
Details
- ISSN :
- 15216551 and 15216543
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- IUBMB Life
- Accession number :
- edsair.doi.dedup.....609977fbe2230abcaa2ec3ab429361c9