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Paraneoplastic neurological autoimmunity and survival in small-cell lung cancer
- Source :
- Journal of Neuroimmunology. :159-162
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- The autoimmune disorder of Lambert-Eaton myasthenic syndrome (LEMS) associates with small cell lung carcinoma (SCLC) in 50-60% of cases. It has been postulated that patients who harbour paraneoplastic neurological syndromes such as LEMS have an improved tumour prognosis compared to other patients with the tumour but without neurological deficit. In this intermediate report of an ongoing prospective study, 100 consecutive patients with biopsy-proven SCLC underwent full neurological examination and serum was taken for autoantibody analysis. Antibodies to voltage-gated calcium channels were detected in 10 patients, however only 4 had clinical and electrophysiological features of LEMS, 1 had limbic encephalitis, whilst the remaining 5 had no neurological signs. A further 6 patients had onconeural antibodies; only one had a paraneoplastic syndrome, sensory neuropathy. The median survival of the four antibody positive LEMS patients (19.6 months) was considerably greater than that for the antibody negative (8.9 months) or antibody positive patients as a whole (10.5 months). Although preliminary, these results suggest that functionally effective antibodies present in the sera of patients with LEMS may confer a survival advantage.
- Subjects :
- Pathology
medicine.medical_specialty
Lung Neoplasms
Paraneoplastic Syndromes
Immunology
Neurological examination
medicine.disease_cause
Antibodies
Autoimmunity
medicine
Humans
Immunoprecipitation
Immunology and Allergy
Prospective cohort study
Survival analysis
medicine.diagnostic_test
biology
business.industry
Limbic encephalitis
Autoantibody
medicine.disease
Small Cell Lung Carcinoma
Survival Analysis
Neurology
biology.protein
Calcium Channels
Neurology (clinical)
Antibody
business
Lambert-Eaton myasthenic syndrome
Subjects
Details
- ISSN :
- 01655728
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....6099a06053a22a51eefa0029b1fb37cd