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Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis
- Source :
- Goos, J A C M, de Cuba, E M V, Coupe, V M H, Karga, C, Belien, J A M, Geldof, A A, Meijer, G A, Hoekstra, O S, Fijneman, R J A, Menke, C W, van Diemen, P M & Diosdado Calvo, MB 2016, ' Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis ', Annals of Surgery, vol. 263, no. 1, pp. 138-145 . https://doi.org/10.1097/SLA.0000000000001109, Annals of Surgery, 263(1), 138. Lippincott Williams and Wilkins, Annals of Surgery, 263(1), 138-145. Lippincott Williams and Wilkins
- Publication Year :
- 2016
-
Abstract
- OBJECTIVE: To investigate the individual and combined prognostic value of HIF1α, SLC2A1, and vascular endothelial growth factor A (VEGFA) in a multi-institutional cohort of patients with resected colorectal cancer liver metastasis (CRCLM). BACKGROUND: In the majority of patients with CRCLM, resection seems not to be curative, despite its curative intent. Overexpression of hypoxia-inducible factor 1α (HIF1α), glucose transporter 1 (SLC2A1; also known as GLUT1), and VEGFA has been associated with tumor progression and poor prognosis of patients with colorectal cancer (CRC). METHODS: Tissue microarrays were generated using CRCLM and patient-matched primary CRC from patients who underwent CRCLM resection between 1990 and 2010. Prognostic value of HIF1α, SLC2A1, and VEGFA was determined by immunohistochemistry. A 500-fold cross-validated hazard rate ratio (HRRav) for overall survival was calculated. RESULTS: HIF1α, SLC2A1, and VEGFA expression could be evaluated in 328, 350, and 335 patients, respectively. High SLC2A1 expression was associated with good prognosis (HRRav, 0.67; P (HRR >1) < 0.01) and high VEGFA expression to poor prognosis (HRRav, 1.84; P (HRR < 1) = 0.02), also after multivariate analysis including established clinicopathological prognostic variables (HRRav, 0.67; P (HRR > 1) < 0.01 and HRRav, 1.50; P (HRR < 1) = 0.02, respectively). SLC2A1 showed prognostic value particularly in patients treated with systemic therapy (P < 0.01), whereas the prognostic value of VEGFA expression was mainly observed in patients not treated with systemic therapy (P < 0.01). Prognosis was especially poor in patients with both low SLC2A1 and high VEGFA expression (P < 0.01). HIF1α expression was not associated with survival. CONCLUSIONS: SLC2A1 and VEGFA expression are prognostic molecular biomarkers for patients with CRCLM with added value to established clinicopathological variables.
- Subjects :
- VEGFA
Vascular Endothelial Growth Factor A
Oncology
endocrine system
medicine.medical_specialty
Colorectal cancer
SLC2A1
HIF1
colorectal cancer
alpha Subunit
Research Support
Metastasis
Internal medicine
Journal Article
medicine
Humans
prognostic biomarker
Non-U.S. Gov't
Survival rate
Retrospective Studies
Glucose Transporter Type 1
Tissue microarray
business.industry
Research Support, Non-U.S. Gov't
Liver Neoplasms
Hazard ratio
Prognosis
Hypoxia-Inducible Factor 1, alpha Subunit
medicine.disease
Survival Rate
liver metastasis
Vascular endothelial growth factor A
Tumor progression
Immunohistochemistry
Surgery
Hypoxia-Inducible Factor 1
Colorectal Neoplasms
business
Subjects
Details
- Language :
- English
- ISSN :
- 00034932
- Database :
- OpenAIRE
- Journal :
- Goos, J A C M, de Cuba, E M V, Coupe, V M H, Karga, C, Belien, J A M, Geldof, A A, Meijer, G A, Hoekstra, O S, Fijneman, R J A, Menke, C W, van Diemen, P M & Diosdado Calvo, MB 2016, ' Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis ', Annals of Surgery, vol. 263, no. 1, pp. 138-145 . https://doi.org/10.1097/SLA.0000000000001109, Annals of Surgery, 263(1), 138. Lippincott Williams and Wilkins, Annals of Surgery, 263(1), 138-145. Lippincott Williams and Wilkins
- Accession number :
- edsair.doi.dedup.....60a6aa878cfc657ba27497e52cd57ccc