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miRNAs expression signature potentially associated with lymphatic dissemination in locally advanced prostate cancer
- Source :
- BMC Medical Genomics, Vol 13, Iss S8, Pp 1-13 (2020), BMC Medical Genomics
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Prostate cancer is one of the most common and socially significant cancers among men. The aim of our study was to reveal changes in miRNA expression profiles associated with lymphatic dissemination in prostate cancer and to identify the most prominent miRNAs as potential prognostic markers for future studies. Methods High-throughput miRNA sequencing was performed for 44 prostate cancer specimens taken from Russian patients, with and without lymphatic dissemination (N1 – 20 samples; N0 – 24 samples). Results We found at least 18 microRNAs with differential expression between N0 and N1 sample groups: miR-182-5p, miR-183-5p, miR-96-5p, miR-25-3p, miR-93-5p, miR-7-5p, miR-615-3p, miR-10b, miR-1248 (N1-miRs; elevated expression in N1 cohort; p miR-1271-5p, miR-184, miR-222-3p, miR-221-5p, miR-221-3p, miR-455-3p, miR-143-5p, miR-181c-3p and miR-455-5p (N0-miRs; elevated expression in N0; p . The expression levels of N1-miRs were highly correlated between each other (the same is applied for N0-miRs) and the expression levels of N0-miRs and N1-miRs were anti-correlated. The tumor samples can be divided into two groups depending on the expression ratio between N0-miRs and N1-miRs. Conclusions We found the miRNA expression signature associated with lymphatic dissemination, in particular on the Russian patient cohort. Many of these miRNAs are well-known players in either oncogenic transformation or tumor suppression. Further experimental studies with extended sampling are required to validate these results.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
lcsh:Internal medicine
lcsh:QH426-470
miRNA-Seq
Locally advanced
03 medical and health sciences
Prostate cancer
Prognostic markers
0302 clinical medicine
Internal medicine
Gene expression
microRNA
Genetics
medicine
Humans
RNA-Seq
lcsh:RC31-1245
Genetics (clinical)
Aged
business.industry
Research
Prostatic Neoplasms
Lymphatic dissemination
Middle Aged
medicine.disease
Human genetics
Gene Expression Regulation, Neoplastic
MicroRNAs
lcsh:Genetics
030104 developmental biology
Lymphatic system
030220 oncology & carcinogenesis
Lymphatic Metastasis
Cohort
DNA microarray
business
Subjects
Details
- Language :
- English
- ISSN :
- 17558794
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- BMC Medical Genomics
- Accession number :
- edsair.doi.dedup.....60baa5dde4acea3decbe56eea15a2bc8