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Frequency Domain Heart Period and QT Interval Variability Markers Are Linked to Arrhythmic Risk in Long QT Syndrome Type 2
- Source :
- CinC
- Publication Year :
- 2020
- Publisher :
- Computing in Cardiology, 2020.
-
Abstract
- Long QT syndrome type 2 (LQT2) is an inherited disease leading to arrhythmias and sudden death often in response to an abrupt sympathetic stimulus. Heart period (HP) and QT interval variability analyses were carried out over asymptomatic (ASYMP, n=10, age 39.0±11.0 yrs, 9 males) and symptomatic (SYMP, n=7, age 41.7±12.8 yrs, 4 males) LQT2 patients. Beat-to-beat series were derived from 24h Holter ECG recordings during daytime and nighttime. In addition to HP and QT mean and variance, we calculated HP power in high frequency (HF, from 0.15 to 0.5 Hz) band as a marker of vagal modulation directed to sinus node and QT power in low frequency (LF, from 0.04 to 0.15 Hz) band as a marker of sympathetic modulation directed to ventricles. HP and QT means exhibited significant day-night changes in both groups. ASYMP showed a shorter corrected QT and a more reactive vagal modulation leading to significant day-night variations of respiratory sinus arrhythmia. By contrast, SYMP had no significant day-night variations of the vagal control. Conversely, SYMP showed a higher sympathetic control during day compared to ASYMP, having a larger QT variance. These findings suggest that frequency domain HP and QT variability markers can account for the different arrhythmic risk of LQT2 ASYMP and SYMP patients.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
Arrhythmic risk
business.industry
Period (gene)
Long QT syndrome
030204 cardiovascular system & hematology
medicine.disease
Sudden death
Asymptomatic
QT interval
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Cardiology
LQTS
030212 general & internal medicine
medicine.symptom
Vagal tone
business
Electrocardiography
Subjects
Details
- ISSN :
- 2325887X
- Database :
- OpenAIRE
- Journal :
- 2020 Computing in Cardiology Conference (CinC)
- Accession number :
- edsair.doi.dedup.....60e7bf7d7141a5973917253e9b259341