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The reliability of magnetic resonance imaging in traumatic brain injury lesion detection
- Source :
- Brain Injury, 26, 12, pp. 1439-50, Brain Injury, 26, 1439-50
- Publication Year :
- 2012
-
Abstract
- Contains fulltext : 109920.pdf (Publisher’s version ) (Closed access) Objective: This study compares inter-rater-reliability, lesion detection and clinical relevance of T2-weighted imaging (T2WI), Fluid Attenuated Inversion Recovery (FLAIR), T2*-gradient recalled echo (T2*-GRE) and Susceptibility Weighted Imaging (SWI) in Traumatic Brain Injury (TBI). Methods: Three raters retrospectively scored 56 TBI patients' MR images (12-76 years old, median TBI-MRI interval 7 weeks) on number, volume, location and intensity. Punctate lesions (diameter /=10 mm). Injury severity was assessed with the Glasgow Coma Scale (GCS), outcome with the Glasgow Outcome Scale-Extended (GOSE). Results: Inter-rater-reliability for lesion volume and punctate lesion count was good (ICC = 0.69-0.94) except for punctate lesion count on T2WI (ICC = 0.19) and FLAIR (ICC = 0.15). SWI showed the highest number of lesions (mean = 30.0), followed by T2*-GRE (mean = 15.4), FLAIR (mean = 3.1) and T2WI (mean = 2.2). Sequences did not differ in detected lesion volume. Punctate lesion count on T2*-GRE (r = -0.53) and SWI (r = -0.49) correlated with the GCS (p < 0.001). Conclusions: T2*-GRE and SWI are more sensitive than T2WI and FLAIR in detecting (haemorrhagic) traumatic punctate lesions. The correlation between number of punctate lesions on T2*-GRE/SWI and the GCS indicates that haemorrhagic lesions are clinically relevant. The considerable inter-rater-disagreement in this study advocates cautiousness in interpretation of punctate lesions using T2WI and FLAIR.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Traumatic brain injury
Neuroscience (miscellaneous)
Glasgow Outcome Scale
Aetiology, screening and detection [ONCOL 5]
Fluid-attenuated inversion recovery
Sensitivity and Specificity
Developmental and Educational Psychology
medicine
Image Processing, Computer-Assisted
Humans
Clinical significance
Child
DCN NN - Brain networks and neuronal communication
Aged
Retrospective Studies
Trauma Severity Indices
medicine.diagnostic_test
Lesion detection
business.industry
Glasgow Coma Scale
Brain
Reproducibility of Results
Magnetic resonance imaging
Middle Aged
medicine.disease
Prognosis
Magnetic Resonance Imaging
Brain Injuries
Susceptibility weighted imaging
Female
Neurology (clinical)
Radiology
business
Subjects
Details
- ISSN :
- 02699052
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Brain Injury
- Accession number :
- edsair.doi.dedup.....60f925f901bf6718fa73de3bab8e9f52