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Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: a cross sectional study
- Source :
- Journal of Infection, Journal of Infection, WB Saunders, 2013, 67, pp.448-57. ⟨10.1016/j.jinf.2013.06.008⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; OBJECTIVES: Mauritania is a highly endemic region for hepatitis B (HBV) and delta (HDV) viruses. No data are available on HDV's impact on the severity of liver disease in consecutive HBV-infected patients in Africa. This study evaluated the degree of liver fibrosis in a cohort of chronic HBV carriers.METHODS: Three-hundred consecutive HBV-infected Mauritanian patients were checked for HDV infection via the detection of anti-HDV antibodies (Ab) and viral RNA. HBV- vs. HBV/HDV-infected patients were compared by physical examination, biological analyses, and the APRI (aspartate aminotransferase to platelet ratio index) and FibroMeter tests for determination of liver fibrosis.RESULTS: More than 30% of the patients had anti-HDVAb. Among these, 62.2% were HDV-RNA positive. Co-infected patients were older (>8-years) than HBV-mono-infected patients. They had more liver tests abnormalities and clinical or ultrasound signs of liver fibrosis. APRI and FibroMeter scores were also significantly increased in these patients. In multivariate analysis, beyond HDVAb, male gender and HBV-VL >3.7logIU/mL were the only markers linked to significant liver fibrosis.CONCLUSIONS: In Mauritania, HDV co-infection worsens liver disease, both clinically and biologically, as confirmed by the APRI and FibroMeter tests. These tests may be useful for the management of delta hepatitis, which is a major health problem in Mauritania.
- Subjects :
- Microbiology (medical)
Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
FIBROMETER
Adolescent
Cross-sectional study
viruses
[SDV]Life Sciences [q-bio]
medicine.disease_cause
Gastroenterology
03 medical and health sciences
Liver disease
0302 clinical medicine
Risk Factors
Internal medicine
Medicine
Humans
Hepatitis Antibodies
hepatitis Delta virus
030304 developmental biology
Aged
Hepatitis B virus
0303 health sciences
Analysis of Variance
business.industry
Coinfection
Mauritania
virus diseases
Hepatitis B
Middle Aged
medicine.disease
Hepatitis D
3. Good health
Infectious Diseases
Cross-Sectional Studies
Immunology
030211 gastroenterology & hepatology
Female
business
hepatitis B virus
Subjects
Details
- Language :
- English
- ISSN :
- 01634453
- Database :
- OpenAIRE
- Journal :
- Journal of Infection, Journal of Infection, WB Saunders, 2013, 67, pp.448-57. ⟨10.1016/j.jinf.2013.06.008⟩
- Accession number :
- edsair.doi.dedup.....61015914b756c8895573a987580011a9