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The Antioxidant and Anti-Inflammatory Properties of Rice Bran Phenolic Extracts
- Source :
- Foods, Volume 9, Issue 6, Foods, Vol 9, Iss 829, p 829 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Oxidative stress and inflammation are known to be linked to the development of chronic inflammatory conditions, such as type 2 diabetes and cardiovascular disease. Dietary polyphenols have been demonstrated to contain potent bioactivity against specific inflammatory pathways. Rice bran (RB), a by-product generated during the rice milling process, is normally used in animal feed or discarded due to its rancidity. However, RB is known to be abundant in bioactive polyphenols including phenolic acids. This study investigates the antioxidant and anti-inflammatory effects of RB phenolic extracts (25, 50, 100, and 250 &micro<br />g/mL) on RAW264.7 mouse macrophage cells stimulated with hydrogen peroxide and lipopolysaccharide. Biomarkers of oxidative stress and inflammation such as malondialdehyde (MDA), intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines such as interleukin-6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), interleukin-10 (IL-10), tumor necrosis factor-&alpha<br />(TNF-&alpha<br />), interleukin-12, p70 (IL-12p70), and interferon-&gamma<br />(IFN-&gamma<br />) were measured in vitro. Treatment with RB extracts significantly decreased the production of MDA, intracellular reactive oxygen species, nitric oxide and pro-inflammatory cytokines (IL-6, IL-12p70, and IFN-&gamma<br />) when compared to the control. It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators.
- Subjects :
- Health (social science)
Antioxidant
antioxidant
Lipopolysaccharide
medicine.drug_class
medicine.medical_treatment
Inflammation
Plant Science
medicine.disease_cause
lcsh:Chemical technology
Health Professions (miscellaneous)
Microbiology
Anti-inflammatory
Article
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
medicine
oxidative stress
lcsh:TP1-1185
polyphenols
030304 developmental biology
anti-inflammatory
rice bran
0303 health sciences
Chemistry
food and beverages
04 agricultural and veterinary sciences
Malondialdehyde
040401 food science
Biochemistry
inflammation
Tumor necrosis factor alpha
medicine.symptom
Oxidative stress
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 23048158
- Database :
- OpenAIRE
- Journal :
- Foods
- Accession number :
- edsair.doi.dedup.....610402dc3fb7c3ee4f73c161b5064c4b
- Full Text :
- https://doi.org/10.3390/foods9060829