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Preventing increased blood pressure in the obese Zucker rat improves severity of stroke
Preventing increased blood pressure in the obese Zucker rat improves severity of stroke
- Source :
- American Journal of Physiology-Heart and Circulatory Physiology. 299:H55-H61
- Publication Year :
- 2010
- Publisher :
- American Physiological Society, 2010.
-
Abstract
- Obesity is a risk factor for stroke, but the determinants of increased stroke risk in obesity are unknown. We have previously reported that obese Zucker rats (OZRs) have a worse stroke outcome and display evidence of remodeling of the middle cerebral artery (MCA), in parallel with hypertension, compared with lean controls. This study tested the hypothesis that hypertension is an essential determinant of cerebral vascular remodeling and increased stroke damage in OZRs. Blood pressure was measured by telemetery in lean and obese rats with and without hydrochlorthiazide (HCT; 2 mg·kg−1·day−1) from 8 to 15 wk of age. A separate group of rats was also chronically fed a low-sodium (LS) diet. Vessel structure was assessed in isolated, pressurized MCAs. Cerebral ischemia was induced for 60 min using an intralumenal suture technique, followed by 24 h of reperfusion. HCT treatment effectively prevented the increase in blood pressure in obese rats; however, the LS diet did not lower pressure. Importantly, infarct size was normalized by HCT after ischemia-reperfusion injury. Additionally, HCT improved the changes in MCA structure observed in untreated OZRs. There were no benefits of the LS diet on stroke injury or vessel structure. These results indicate that increased pressure is essential for driving the changes in infarct size in OZRs.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Physiology
Hemodynamics
Blood Pressure
Severity of Illness Index
Central nervous system disease
Risk Factors
Physiology (medical)
Internal medicine
Severity of illness
medicine
Animals
Telemetry
Obesity
cardiovascular diseases
Risk factor
Stroke
Antihypertensive Agents
Vascular disease
business.industry
Infarction, Middle Cerebral Artery
Articles
Blood Pressure Monitoring, Ambulatory
Diet, Sodium-Restricted
medicine.disease
Rats
Rats, Zucker
Disease Models, Animal
Hydrochlorothiazide
Blood pressure
Endocrinology
Hypertension
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15221539 and 03636135
- Volume :
- 299
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Heart and Circulatory Physiology
- Accession number :
- edsair.doi.dedup.....6105244dfcbd33d08dce5b6d28c320d4
- Full Text :
- https://doi.org/10.1152/ajpheart.01111.2009