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Hydrogen Sulfide Protects against Chronic Unpredictable Mild Stress-Induced Oxidative Stress in Hippocampus by Upregulation of BDNF-TrkB Pathway
- Source :
- Oxidative Medicine and Cellular Longevity, Vol 2016 (2016), Oxidative Medicine and Cellular Longevity
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway. We showed that NaHS (0.03 or 0.1 mmol/kg/day) ameliorates the level of hippocampal oxidative stress, including reduced levels of malondialdehyde (MDA) and 4-hydroxy-2-trans-nonenal (4-HNE), as well as increased level of glutathione (GSH) and activity of superoxide dismutase (SOD) in the hippocampus of CUMS-treated rats. We also found that H2S upregulated the level of BDNF and p-TrkB protein in the hippocampus of CUMS rats. Furthermore, inhibition of BDNF signaling by K252a, an inhibitor of the BDNF receptor TrkB, blocked the antioxidant effects of H2S on CUMS-induced hippocampal oxidative stress. These results reveal the inhibitory role of H2S in CUMS-induced hippocampal oxidative stress, which is through upregulation of BDNF/TrkB pathway.
- Subjects :
- 0301 basic medicine
Male
Aging
medicine.medical_specialty
Article Subject
Tropomyosin receptor kinase B
Hippocampal formation
Sulfides
medicine.disease_cause
Biochemistry
Hippocampus
Superoxide dismutase
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
Stress, Physiological
Internal medicine
medicine
Animals
Receptor, trkB
Hydrogen Sulfide
lcsh:QH573-671
Brain-derived neurotrophic factor
biology
lcsh:Cytology
Brain-Derived Neurotrophic Factor
Cell Biology
General Medicine
Glutathione
Malondialdehyde
equipment and supplies
Rats
Up-Regulation
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
nervous system
biology.protein
030217 neurology & neurosurgery
Oxidative stress
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19420994 and 19420900
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....61078adb8b57f983c21fd52924ab283c