Na V 1.5 in embryonic heart development

The voltage‐gated sodium (NaV) channel is essential for cardiomyocyte function. It is responsible for generating the rising phase of the cardiac action potential. The channel consists of a pore‐forming, α‐subunit, whose main cardiac isoform is NaV1.5, and one or two associated β‐subunits. Moreover, it is part of a macromolecular complex including a diverse set of interacting proteins, some of which are implicated in regulating its localization to specialized membrane domains of the cardiomyocyte sarcolemma